|
KMID : 1214920150210020227
|
|
Soonchunhyang Medical Science
2015 Volume.21 No. 2 p.227 ~ p.231
|
|
|
Effect of Cabergoline Treatment on Cushing’s Disease Caused by Pituitary Macroadenoma after Incomplete Transsphenoidal Surgery
|
|
Yoo Eun-Jung
Yoo Eun-Soo
Kim Young-Geon
Choi Yong-Jun
Han Seung-Jin
Chung Yoon-Sok
|
|
|
Abstract
|
|
|
|
The present case involves a 56-year-old woman with Cushing’s disease due to pituitary macroadenoma. The patient had suffered from central obesity, general weakness for 1 year. Her serum cortisol levels were elevated throughout the observation period and the dexamethasone test failed to suppress the cortisol secretion. Plasma adrenocorticotropic hormone (ACTH) levels were significantly elevated (386 pg/mL). Sellar magnetic resonance imaging revealed a 3.1-cm pituitary tumor occupying the sellar region with extension to parasellar area. The pituitary mass was removed by transsphenoidal surgery incompletely and was pathologically identified as compatible to ACTH-producing pituitary adenoma by immunohistochemistry. Thereafter, cabergoline (1 mg/wk) was administered for the remnant adenoma, which gradually reduced ACTH levels in 7 days before starting radiation therapy. This case demonstrates the efficacy of cabergoline to treat Cushing’s disease caused by pituitary macroadenoma.
|
|
|
KEYWORD
|
|
|
Adrenocorticotropic hormone, Cushing syndrome, Pituitary neoplasms, Cabergoline
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|